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Rabies Vaccine -- 3 yr Vaccine Relabeled as 1 yr

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#1
Kris L. Christine

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The USDA allows vaccine manufacturers to relabel their 3 year rabies vaccines as 1 year products. This link http://www.calmanima...com/vaccine.htm , you will be taken to the Calm Animal Care website, which has posted Colorado State University's Small Animal Vaccination Protocol for its veterinary teaching hospital, which states:"Even with rabies vaccines, the label may be misleading in that a three year duration of immunity product may also be labeled and sold as a one year duration of immunity product." "In the case of Defensor 1 and Defensor 3 vaccines made by Pfizer, testing is the only difference between the products. 'The formulations are the same, but regulatory requirements for the one- and three-year vaccines are different, requiring distinct and separate studies for each label,' said Pfizer spokesman Richard Chambers." States Consider Controlling Rabies Vaccination Intervals, by Edie Lau The Veterinary Information Network News Service 8/12/11 http://news.vin.com/...articleId=19501 According to Dr. Ronald Schultz of the University of Wisconsin School of Veterinary Medicine, "There is no benefit from annual rabies vaccination and most one year rabies products are similar or identical to the 3-year products with regard to duration of immunity and effectiveness. However, if they are 1 year rabies vaccines, they must be legally given annually!" from What Everyone Needs to Know about Canine Vaccines http://www.puliclub....ne Vaccines.htm In an April 1, 2008 DVM360 article entitled, Canine Vaccine Update (Proceedings) http://veterinarycal...e/detail/562405 by Dr. Craig Datz states that, "..some brands of rabies vaccine are identical whether labeled as 1- or 3-year..."2006 Canine & Feline Vaccination Guidelines, A Forum on Issues and Controversies by Dr. Richard B. Ford, DVM, Professor of Medicine, North Carolina State University College of Veterinary Medicine http://www.hcvma.org...RichardFord.pdf Table 2 on Page 4 states: Vaccine Type: Rabies, 1-year: Minimum Duration of Immunity: 3 Years (must be administered annually)

#2
acetoo

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All my pets get 3 year Rabies vaccine every 2 years. The reason for this is, I see no harm to the pets and in my area there are confirmed cases of Rabies on a regular basis. I myself would rather be safe than sorry as Rabies is no laughing matter and I would hate to euthanize my pets because they were exposed to a Rabid animal and I was a day late getting that 3 year vaccine. I personally don't ever want to be exposed as there is no cure and Rabies is a horrible death. Oh yeah, it's pretty cheap too.

#3
Kris L. Christine

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[quote name='acetoo;700451]All my pets get 3 year Rabies vaccine every 2 years. The reason for this is' date=' I see no harm to the pets and in my area there are confirmed cases of Rabies on a regular basis. I myself would rather be safe than sorry as Rabies is no laughing matter and I would hate to euthanize my pets because they were exposed to a Rabid animal and I was a day late getting that 3 year vaccine. I personally don't ever want to be exposed as there is no cure and Rabies is a horrible death. Oh yeah, it's pretty cheap too.[/QUOTE']Acetoo, you are overvaccinating your dogs and putting them at needless risk for adverse reactions, which can be quite harmful & possibly lethal (see below). According to the CDC (see below), it is unlikely that a fully vaccinated dog or cat (one that has had 2 properly administered rabies vaccines) will become infected with rabies. Further, immunity to rabies does not suddenly disappear on the 3rd anniversary of vaccination -- the science has demonstrated a minimum duration of immunity of 5 years by challenge (see below) and 7 years serologically for the canine rabies vaccine.Center for Disease Control Morbidity and Mortality Weekly Report March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/m...ml/00041987.htm"A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. " The Journal of the American Veterinary Medical Association published a report in its April 1, 2008 issue, Vol. 232, No. 7, entitled: Postmarketing Surveillance of Rabies Vaccines for Dogs to Evaluate Safety and Efficacy. Despite the extreme under-reporting of vaccinal adverse reactions, this report states on the second page that between April 1, 2004 and March 31, 2007, the Center for Veterinary Biologics, "nearly 10,000 adverse event reports (all animal species) were received by manufacturers of rabies vaccines..........Approximately 65% of the manufacturer's reports involved dogs."The report further states on the second page that: "Rabies vaccines are the most common group of biological products identified in adverse event reports received by the CVB," They give the following description of the adverse reaction followed by the % of dogs affected: Vomiting-28.1%, Facial Swelling-26.3%, Injection Site Swelling or Lump-19.4%, Lethargy-12%, Urticaria-10.1%, Circulatory shock-8.3%, Injection site pain-7.4%, Pruritus-7.4%, Injection site alopecia or hair loss-6.9%, Death-5.5%, Lack of Consciousness-5.5, Diarrhea-4.6%, Hypersensitivity (not specified)-4.6%, Fever-4.1%, Anaphylaxis-2.8%, Ataxia-2.8%, Lameness-2.8%, General signs of pain-2.3%, Hyperactivity-2.3%, Injection site scab or crust-2.3%, Muscle tremor-2.3%, Tachycardia-2.3%, and Thrombocytopenia-2.3%.French challenge studies conducted by Michel Aubert published in 1992 demonstrated that dogs were immune to a rabies challenge (a challenge is when high doses of virulent virus are injected into a dog) 5 years after vaccination. Serological studies conducted by Dr. Ronald Schultz at the University of Wisconsin School of Veterinary Medicine have demonstrated a minimum duration of immunity of 7 years. (On page 13 of the Special Report of the American Animal Hospital Association (AAHA) Canine Vaccine Task Force: 2003 Canine Vaccine Guidelines, Recommendations, and Supporting Literature, http://www.leerburg....cial_report.htm it states: "The minimum DOI for killed rabies vaccine based on challenge studies is 3 years; based on antibody titers, it is considered to be up to 7 years [Table 2]. ")

#4
acetoo

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Better safe than sorry and after 30 years of using vaccine like this I have yet to see any adverse effects on my pets. Occassionally an animal will have swelling or a rash at the injection site, but an injection of Diphenhydramine ahead of time is usually plenty to keep those at bay.

#5
Cooper Ray

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I saw an expose on a vet doing a monthly "clinic" at a petstore and he only sold the "2 year" Rabies vaccine. The assistants told customers it was a 2 year vaccine and the only vaccine they offered. When the vet was called to task on it, he admitted they were really three year vaccines, but he recommended them every two years, because pet owners "forget" to revaccinate. They send out the flippin reminder card. What's to forget? Following the initial and booster, once every three years is all they need.

#6
Kris L. Christine

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Better safe than sorry .....

Rabies vaccines have a minimum duration of immunity of 3 years by challenge and 7 years serologically. Giving an annual rabies booster does not enhance immunity any more than getting a tetanus booster every year rather than the 10 year national standard.On page 13 of the Special Report of the American Animal Hospital Association (AAHA) Canine Vaccine Task Force: 2003 Canine Vaccine Guidelines' date=' Recommendations, and Supporting Literature[/b'] http://leerburg.com/special_report.htm, it states: "The [b]minimum DOI for killed rabies vaccine based on challenge studies is 3 years; based on antibody titers, it is considered to be up to 7 years [Table 2]. "

#7
Kris L. Christine

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[quote name='Cooper Ray;700627]I saw an expose on a vet doing a monthly "clinic" at a petstore and he only sold the "2 year" Rabies vaccine. The assistants told customers it was a 2 year vaccine and the only vaccine they offered. When the vet was called to task on it' date=' he admitted they were really three year vaccines, but he recommended them every two years, because pet owners "forget" to revaccinate. They send out the flippin reminder card. What's to forget? Following the initial and booster, once every three years is all they need.[/QUOTE']Here are the links to all 4 parts of that news story:

#8
jakksmum

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thanks , Kris , good information to have.....my previous vet gave my little chihuahua a rabies[ plus all the other ones] shot every year and when she swelled up like a shar pei , he just added more junk to the shots. I didn't know you didn't have to have all those shots every year , and MY VET NEVER TOLD ME DIFFERENT!

#9
porterk

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My vet gives them every three years after the first shot, but I oftened wondered if the one year does was a "lighter" does - guess not? Unfortunately Porter is allergic to the 3 yr. dose and cannot ever have it again - he went into shocked when he got it last time and nearly passed out (his mouth turned dry and he couldn't breath) - Dr. said no more rabies shots for Porter (of course that didn't happen when he got that initial one).

#10
Ups N Downs

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Kris, I just want to thank you for helping us be informed when it comes to vaccinating our animals. Having the information you post here is invaluable and I know I have found myself searching the info that you post when it comes to my dogs. Especially now that Niles is older (11) and may not need all the vaccines that he is getting. I am hoping to titter him this year (in Nov) instead of just blindly vaccinating him.

#11
Kris L. Christine

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shot every year and when she swelled up like a shar pei , he just added more junk to the shots. I didn't know you didn't have to have all those shots every year , and MY VET NEVER TOLD ME DIFFERENT!

You're very welcome. Crested owners, because their dogs are small, must be especially vigilant in making sure their animals are not overvaccinated, as small dogs have been shown to have more adverse reactions to vaccination than larger breeds (see below).The quotes in red below are from the attached scientific report covering adverse events within 3 days of vaccination in dogs over the course of 2 years. Reports of dogs having vaccinal adverse reactions within the same time frame were not included if heartworm medication had been administered along with the vaccines. This study did not include adverse reactions such as development of fibrosarcomas and/or other conditions which take longer than 3 days to develop.Moore, George E. et als., Adverse events diagnosed within three days of Vaccine Administration in Dogs, Journal of the American Veterinary Medical Association, Vol 227, No. 7, October 1, 2005Animals—1,226,159 dogs vaccinated at 360 veterinary hospitals.Results—4,678 adverse events (38.2/10,000 dogs vaccinated) were associated with administration of 3,439,576 doses of vaccine to 1,226,159 dogs. The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs ≤ 10 kg (22 lb) and 12% in dogs > 10 kg. Conclusions and Clinical Relevance—Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination.Records for dogs that received both an injectable heartworm preventive and a vaccine during the same office visit were not included in analyses.Population—In the 2-year study period, 4,531,837 vaccine doses were administered to 1,537,534 dogs at 360 veterinary hospitals.Among breeds with 5,000 or more dogs vaccinated, Dachshund, Pug, Boston Terrier, Miniature Pinscher, and Chihuahua breeds had the highest rates of VAAEs with 121.7, 93.0, 83.8, 76.4, and 76.1 adverse events/10,000 dogs vaccinated, respectively (Table 1). The VAAE rate for mixed-breed dogs was in the bottom quintile of all rates.The VAAE rates decreased significantly as body weight increased (P for trend < 0.001; Figure 1). For all vaccines or for rabies vaccine alone, the VAAE rate for 10.1- to 45.0-kg (22.2- to 99.0-lb) dogs was approximately half the rate for dogs that weighed 0 to 10.0 kg (0 to 22.0 lb; P < 0.001; Figure 2). For rabies vaccine administered alone, VAAE rates/10,000 dogs that weighed 0 to 10.0 kg, 10.1 to 45.0 kg, and > 45 kg were 32.1 (222/69,178), 15.3 (69/45,088), and 0.0 (0/1,966), respectively.The risk of a VAAE significantly increased as the number of vaccines administered per office visit increased (P for trend < 0.001).In all dogs, each additional vaccine administered per office visit increased the rate of a VAAE by 24.2%; the rate increase was significantly (P <0.001) greater in dogs that weighed 0 to 10.0 kg, compared with dogs that weighed 0.1 to 45.0 kg (27.3% vs 11.5%, respectively; Figure 4). The 3 dogs with recorded deaths each had received ≥ 4 vaccines at their last office visit.The lowest rate was observed with parenteral administration of Bordetella vaccine (15.4/10,000; 82 VAAEs/53,238 doses), and the highest rate was observed with Borrelia (Lyme disease) vaccine (43.7/10,000; 132 VAAEs/30,201 doses).The risk of a VAAE in this study population was inversely related to a dog’s weight.Factors known to cause vaccine reactions include the primary vaccine agent or antigen, adjuvants, preservatives, stabilizers, and residues from tissue cultures used in vaccine production.The overall formulation of various vaccine components (eg, antigen, adjuvants, and diluent) is proprietary information that was unavailable for analysis in our study; thus, the variation in VAAE rates among single-antigen vaccinesmay not be solely attributable to the primary vaccine antigen.... because of genetic heterogeneity, the relatively low VAAE rate observed in mixed-breed dogs suggests that laboratory safety trials that use such dogs may underestimate the VAAE rates that would occur in purebred dogs. This is important because purebred dogs comprise at least two thirds of the US dog population.The risk of allergic reaction has been reported to increase after the third or fourth injection of a vaccine (ie, a booster response).Neutering appeared to increase risk of a VAAE more than sex. Females mount stronger immune responses after vaccination or infection than males because of a dimorphic enhancing effect of estrogens and a protective effect of androgens._____________________________________________________________________ Below are links to excellent information on veterinary vaccines from authoritative sources:Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz http://www.cedarbayv...of_immunity.htm What Everyone Needs to Know about Canine Vaccines, Dr. Ronald Schultz http://www.puliclub....ne Vaccines.htm Age and Long-term Protective Immunity in Dogs and Cats, Dr. Ronald Schultz et als., Journal of Comparative Pathology January 2010 http://www.sciencedi...1fa65abea55dbd8 Genetically Engineered and Modified Live Virus Vaccines;Public Health and Animal Welfare Concerns by Michael W. Fox BVetMed,PhD,DSc.MRCVS http://www.twobitdog...89-cca1d1a81c38Vaccination: An Overview Dr. Melissa Kennedy, DVM360 http://veterinarycal...l.jsp?id=568351World Small Animal Veterinay Association's 2010 Guidelines for the Vaccination of Dogs and Cats http://www.wsava.org/VGG1.htm (scroll down to Vaccine Guidelines 2010 http://www.wsava.org...delines2010.pdf World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm Scroll down to Vaccine Guidelines 2007 (PDF) The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at http://www.leerburg....cial_report.htm .The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at http://www.aahanet.o...es06Revised.pdfVeterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at http://www.newvaccin...nprotocols.com/ October 1, 2002 DVM Newsletter article entitled, AVMA, AAHA to Release Vaccine Positions, http://www.dvmnewsma...il.jsp?id=35171 July 1, 2003 DVM Newsletter article entitled, What Do We Tell Our Clients?, Developing thorough plan to educate staff on changing vaccine protocols essential for maintaining solid relationships with clients and ensuring quality care http://www.dvmnewsma...il.jsp?id=61696July 1, 2003, DVM Newsletter article, Developing Common Sense Strategies for Fiscal Responsibility: Using an interactive template to plan service protocol changes http://www.dvmnewsma...il.jsp?id=61694Animal Wellness Magazine Article Vol. 8 Issue 6, How Often Does he REALLY Need A Rabies Shot Animal Wellness Magazine - devoted to natural health in animalsThe Rabies Challenge Animal Wise Radio InterviewListen to Animal Wise (scroll down to The Rabies Challenge 12/9/07)The Vaccine Challenge Animal Talk Naturally Online Radio Show ยป The Vaccine Challenge - Show #91Rabies Prevention -- United States, 1991 Recommendations of the Immunization Practices Advisory Committee (ACIP), Center for Disease Control's Morbidity and Mortality Weekly March 22, 1991 / 40(RR03);1-19 http://www.cdc.gov/m...ml/00041987.htm "A fully vaccinated dog or cat is unlikely to become infected with rabies, although rare cases have been reported (48). In a nationwide study of rabies among dogs and cats in 1988, only one dog and two cats that were vaccinated contracted rabies (49). All three of these animals had received only single doses of vaccine; no documented vaccine failures occurred among dogs or cats that had received two vaccinations. "

#12
Kris L. Christine

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[quote name='Ups N Downs;700861]Kris' date=' I just want to thank you for helping us be informed when it comes to vaccinating our animals. Having the information you post here is invaluable and I know I have found myself searching the info that you post when it comes to my dogs. Especially now that Niles is older (11) and may not need all the vaccines that he is getting. I am hoping to titter him this year (in Nov) instead of just blindly vaccinating him.[/QUOTE'] It's my pleasure, & I'm happy to know that you're finding the information useful.

#13
Puffalicious Momma

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I know I am very grateful .... No more overvaccinating my dogs since Haleys terrible reaction and Kris' very credible info ... thank you !!

#14
bailey

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my schnoodle who is small (10 lbs) & is a senior now has horrible reactions to vaccines even when they give her something with it so she doesn't react. it's getting worse as she is getting older. no more vaccines for her!

#15
GrandCynth

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This information is so important, and isn't just one person's opinion. Kris Christine has taken considerable time, and effort, to site numerous scientific facts behind the negatives of over vaccinating our pets. Please take the time to read through this information. Knowledge is power, and just may save your pet's life. Just because your dog doesn't have a reaction within hours, or even a fews days, doesn't mean that it has not been negatively affected.I am not anti-vaccine, but I am for responsible vaccination, based on the breed of dog, lifestyle of the dog, and age of the dog. If there is a gray area, you can always have your dog titer tested, to see if it has immunity. If it does, there is no need to re-vaccinate, as that could actually have dire consequences. I have personal experience with that.Please feel free to share any of the above information Kris has provided us, with your own vets.




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